Simultaneous Estimation and Validation for Determination of Lamivudine and Zidovudine in Human Plasma By LCMS/MS Method
نویسندگان
چکیده
منابع مشابه
HPTLC-densitometry method development and validation for simultaneous determination of abacavir, lamivudine and zidovudine in combined dosage form
A simple, accurate and precise HPTLC- densitometry method for the simultaneousdetermination of abacavir, lamivudine and zidovudine in pharmaceutical tablet has beendeveloped. Separation of tablet components was performed on aluminum backed HPTLC plates(silica gel 60 F254 20×20 cm with 0.2 mm thickness, Camag, Muttenz, Switzerland ) usingmethanol : chloroform : acetonitrile (4 : 8 : 3 v/v). Good...
متن کاملhptlc-densitometry method development and validation for simultaneous determination of abacavir, lamivudine and zidovudine in combined dosage form
a simple, accurate and precise hptlc- densitometry method for the simultaneousdetermination of abacavir, lamivudine and zidovudine in pharmaceutical tablet has beendeveloped. separation of tablet components was performed on aluminum backed hptlc plates(silica gel 60 f254 20×20 cm with 0.2 mm thickness, camag, muttenz, switzerland ) usingmethanol : chloroform : acetonitrile (4 : 8 : 3 v/v). good...
متن کاملDevelopment and Validation of a HPLC Method for Determination of Pefloxacin in Tablet and Human Plasma
Objective(s) Developing and validating a simple, efficient, reproducible and economic reversed phase high performance liquid chromatographic (RP-HPLC) method for the quantitative determination of pefloxacin in bulk material, tablets and in human plasma. Materials and Methods A shim-pack CLC-ODS column and a mobile phase constituting acetonitrile: 0.025 M phosphoric acid solution (13:87 v/v, ...
متن کاملBioanalytical method development and validation for the simultaneous estimation of lamivudine and stavudine in human plasma by HPLC.
Lamivudine (Fig. 1), chemically 2í,3í-dideoxy-3í-thiacytidine, is a pyrimidine analogue, whereas stavudine (Fig. 1), 2í,3í-didehydro-3ídeoxythymidine, is a thymidine analogue. Both are reverse transcriptase inhibitors reported to be active against HIV-1, HIV-2 and hepatitis B virus. (ñ) Enantiomer of lamivudine has less cytotoxic and greater antiviral activity than its (+) enantiomer. It shows ...
متن کاملSimultaneous estimation of Zidovudine and Lamivudine tablets by RP-HPLC method
A high-performance liquid chromatographic method was developed and validated for the determination of two antiretroviral drugs viz. Zidovudine and Lamivudine in combined pharmaceutical tablets. The different analytical performance parameters such as linearity, precision, accuracy, specicity, limit of detection (LOD) and limit of quantication (LOQ) were determined. Chromatography was carried o...
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ژورنال
عنوان ژورنال: E-Journal of Chemistry
سال: 2012
ISSN: 0973-4945,2090-9810
DOI: 10.1155/2012/716963